Effects of Catalase Over-expression on Aging :: Biology Age

accession What exactly causes the infirmities of old board? According to the dethaw-radical theory of aging, oxidative deterioration caused by ROS ( labile type O species) is the main culprit. This paper focuses on a correction that partly supports this theory by showing that murine life baffle can be extended by an overexpression of human catalase in mitochondria. The particularised paper that this is based on is Extension of Murine Life baffle by Overexpression of Catalase Targeted to Mitochondria by Samuel E. Schriner et al. Another paper that was used in the wind of this paper is The Anti-Aging Sweepstakes Catalase Runs for the ROSes by Richard A. Miller. These scientific papers are summaries of the experiments carried out by Schriner and his group dealing with the topic of catalase-overexpression and its effect on murine lifespan. However, it is all-important(a) to remember that this is a topic still under much debate. though these experiments do not pr ovide us with a definat cureall for aging, it is believed by umpteen that the data aquired from them point us to one of the major culprits of aging and age related diseases, ROSs. Why the fuss over R.O.S.? Attempts to prolong longevity bugger off been a major endeavor in science and several hypotheses turn in been proposed about the major causes. Scientists have focused on the role of reactive group O species in longevity through investigations using mice models. Reactive oxygen species role in aging processes is also known as the free radical theory of aging. Scientists have found that reactive oxygen species onslaught molecules of biological systems and are the main cause for the functional decline of electric organ systems that lead to eventual death. Various experiments were conducted to investigate the role of reaction oxygen species using transgenic mouse models. Specifically, the purpose of these experiments are to determine if minimizing the level of ROS (r eactive oxygen species) in certain organelles in mice have any effect on the overall health and lifespan of the mouse. The hypothesis was tested by amplifying a certain gene in mouse DNA that expresses catalase, an enzyme that breaks down the ROSs. However, preliminary to beginning the experiments, transgenic mice are necessary for the experimentation.Development of a Transgenic Mouse A transgenic mouse is a mouse that has had a specific gene, in this episode the human catalase gene, inserted into its genome.